Cannabis suppositories how does it work?

The most common form of the suppository is the rectal suppository, a very effective method of administration for the delivery of cannabinoids. Suppositories are designed to dissolve or melt and this allows the active ingredients (in this case cannabinoids) to enter the bloodstream via the blood vessels lining the rectum. There are many advantages to this method of administration: Works faster than when taken orally.
Avoids the production of the very psychoactive 11-Hydroxy-THC. Requires a lower dose due to increased bioavailability.
Very effective for delivering cannabinoids to people who cannot take them orally due to nausea and vomiting.
The effects are longer lasting.

How to Make Cannabis Suppositories

Suppositories are very easy to make. Add half a gram of oil to three grams of natural cocoa butter, slowly melt, and mix thoroughly. Professional suppository molds are available online, or alternatively, you can create a simple mold by wrapping tin foil around your little finger. If you have made capsules for oral application, these can also be used as a
suppository. However, some people may find that they need to apply a small amount of lubricant to aid insertion.
Studies indicate that using THC-HS suppositories for rectal administration offers around twice the bioavailability of oral administration.23 Converting THC into the ester THC-HS makes it water soluble, improving uptake and bioavailability. However, the esterification of cannabinoids is beyond the scope of this book.